• Arrhythmogenicity of catheter-based skeletal myoblast injections guided by
  intracardiac echo in infarcted adult miniature swine

• Transplantation of autologous bone marrow mononuclear cells does not alter arrhythmia threshold

• Epicardial fibroblast injection modifies electrical conduction in atrial myocardium

• Autologous fibroblast transplantation into myocardial infarcts in swine: effects on arrhythmogenesis and arrhythmic threshold

• Effects on cardiac function and arrhythmia threshold of high dose of skeletal myoblast injection in swine with myocardial infarction

• Identification and characterization of different cell types involved in vascular injury and repair following balloon angioplasty and stenting

• Comprehensive assessment of the cellular recruitment, proliferation and differentiation events involved in host response to extracellular matrix scaffold resorbable biomaterial implant for repair of the infarcted heart

• Identification of molecular targets, oncoproteins and cytokines to detect modulation of signal transduction pathways of different antiproliferative, anti-neoplastic and anti-inflammatory agents in the investigation of stent restenosis. Includes monitoring of cytotoxic and cytostatic effects of key molecular regulators of the cell cycle

• Left ventricular free wall replacement with a tissue-engineered patch

• Polymer aortic valve replacement

• Ischemic heart creation and cell injection

• Pressure sensor implantation in the heart

• Heterotopic heart transplantation

• Ischemic hind limb model and cell injection

• Interventional procedures: studies involving PTCA, brachytherapy, and coronary stents (baremetal, drug-eluting and bioerrodable)

• Patch implants in infarcted myocardium

• Broad range of histomorphometry and histopathology evaluations

• NIH-sponsored, internally funded and corporate-sponsored tissue engineering studies in areas including:

o Vascular grafts

o Heart valve replacement

o Myocardial tissue repair